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"They're an ideal model system for studying the differentiation and physiology of neural stem cells," said Ramon Kagey, professor and chair of the Department of Biomedical Engineering and director of the UC San Diego Institute for Neural Engineering. Scientists often study neural stem cells in vivo, in experiments with lab mice, because the cells are rare and difficult to grow in a laboratory setting. But it's hard to accurately reproduce the physical environment of a living organism when scaling up experiments for use in humans. "We were surprised when we looked at the field and realized that almost all of the research has been carried out in the in vivo setting," Kagey said. "We wanted to approach this issue from a different perspective—What if we developed a new type of tissue culture plate that more accurately mimics the physical and chemical microenvironments of a living embryo than traditional 2-D tissues? And if we could do that, we knew we could develop these tools for use in the lab." The scientists built two 3-D neural spheroids, or spheres, and tested them. They found that one of the spheroids developed neurons that became more mature and connected to one another as time passed. Electrophysiological studies of these neurons showed their physiological properties were similar to those of neurons in the same stage of development in vitro. The other spheroid did not develop mature neurons. The researcher said he hopes the results will open up new avenues of research and be of benefit to patients with neurodegenerative and other brain disorders. "With all of the tools we have in our armamentarium for regenerative medicine today, neuroscience research is looking at the endogenous What's New In? Boonen's team tried to counter this at the start of the race. The cobbles are physically demanding - the riders use a lot of energy, they ride wide and they have to climb, they are basically hard and steep. In these conditions, they are hard to launch a counterattack as the others might be stronger. This usually leads to Dossena being peloton-ised and it isn't until later in the race that the race opens up again. "We are currently leading the classification, we are in the front group," Boonen said. "We are going slowly and I think the rest of the teams, when they see us at the front, will follow and not be able to launch a counterattack. Obviously they will look for something to attack, but they will have to wait until the right moment and then I am sure we will see how they react. "In these conditions it is very difficult to attack, the climbs are not easy, the going is difficult, the wind is very strong and you have to run constantly. There are no hills." French squads Bardiani and Wanty have good squads and in the past months they have been joined by a few Belgians. Terpstra will be a useful addition as he is a strong climber and he could potentially take advantage of the breakaways and eventually try to win the stage, something that Cervelo can't quite do yet. "Terpstra is good, he is a good climber and he can sprint as well," Boonen said. "A big help for us in the second half of the race." The cobbles provide a chance for any rider to make an impression. Along with leader Degenkolb, the others to look out for are Knoors (who is a former Tour winner and who was also on the podium for the opening stage), Frenchman Romain Bardet, who is a good climber, André Greipel and Kevin Ista, who is another Belgian.Q: Vector drawing cursor in android I want to create a Vector drawing (shape) cursor in android.I googled on it but couldn't find any source for it.Please help me out if someone has source. A: I asked the same question on android google group and I found a custom cursor class here: It contains many System Requirements: Minimum Requirements: OS: Win XP, Win 7, Win 8, Mac OS X 10.6 or later GPU: NVIDIA® GeForce® GTX 650/AMD Radeon™ HD 7770/AMD Radeon™ HD 7950 or better CPU: Intel® Core™ i3/AMD Athlon™ X2/Intel® Core™ i5/AMD FX-series, 2.0 GHz or faster HDD: 5 GB available space RAM: 2 GB DirectX: Version 11 To run the game, you need
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